Descrição
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides and the different clinical forms of the disease are associated with the host immune responses. Quantitative trait loci mapping analysis was performed to assess genetic variants associated with mononuclear-cells-derived cytokines induced by P. brasiliensis on 158 individuals. We identified the rs11053595 SNP, which is present in the CLEC7A gene (encodes the Dectin-1 receptor) and the rs62290169 SNP located in the PROM1 gene (encodes CD133) associated with the production of IL-1β and IL-22, respectively. Functionally, the blockade of the dectin-1 receptor abolished the IL-1β production in P. brasiliensis-stimulated PBMCs. Moreover, the rs62290169-GG genotype was associated with higher frequency of CD38+ Th1 cells in PBMCs cultured with P. brasiliensis yeasts. Therefore, our research indicates that the CLEC7A and PROM1 genes are important for the cytokine response induced by P. brasiliensis and may influence the Paracoccidioidomycosis disease outcome.
Ogi Cardiff
Pharmaceuticals, Free Full-Text
Term Papers Online: 90+ FREE Websites for Your Paper
Jo's Styles Font Download
Sustainability, Free Full-Text
Dojo Font Download - Fonts4Free
_550width.png)
Special Ed Connection
ACCESS TO INFORMATION RESOURCES (for Teaching, Learning and Research) - ppt download
The Journal of Finance - Wiley Online Library
Boots fans can get £369-worth of free full-size premium makeup and anti-ageing skincare from Bobbi Brown, Huda, Too Faced and Urban Decay - Manchester Evening News
Full List of Free Xbox 360 Games
de
por adulto (o preço varia de acordo com o tamanho do grupo)
