2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
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Descrição
Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation. - Abstract - Europe PMC
Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases
2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo
Methylation of viral mRNA cap structures by PCIF1 attenuates the antiviral activity of interferon-β
The broad-spectrum antiviral functions of IFIT and IFITM proteins
RNA 2′-O-methylation modification and its implication in COVID-19 immunity
Messenger RNA Cap Methylation in Vesicular Stomatitis Virus, a Prototype of Non‐Segmented Negative‐Sense RNA Virus
Regulation of antiviral innate immunity by chemical modification of viral RNA - Li - 2022 - WIREs RNA - Wiley Online Library
Viruses, Free Full-Text
Molecular mechanisms of coronavirus RNA capping and methylation
Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations
Pathogens, Free Full-Text
2'-O-Methylation of the second transcribed nucleotide within the mRNA 5' cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion. - Abstract - Europe PMC
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